Review Articles

Targeting ADAM10 in Cancer and Autoimmunity. 

Smith TM Jr, Tharakan A, Martin RK.

Front Immunol. 2020;11:499.

A new look at IgE beyond allergies

Luker AJ, Lownik JC, Conrad DH, Martin RK.

F1000Res. 2019 May 24;8. pii: F1000 Faculty Rev-736.

Research Articles

Identification of the transgene insertion site for an adipocyte-specific adiponectin-cre model and characterization of the functional consequences

Farrar JS, Lownik JC, Way GW, Rodriguez MC, Celi FS, Martin RK.

Adipocyte. 2021 DOI: 10.1080/21623945.2021.1880083

Ceremide in apoptosis and oxidative stress in allergic inflammation and asthma

James BN, Oyeniran C, Sturgill JL, Newton J, Martin RK, Bieberich E, Weigel C, Maczis M, Palladino END, Lownik JC, Trudeau BA, Cook-Mills JM, Wenzel S, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2020 Oct 29;20091-6749(20)31501-3

 Adipocyte ADAM17 plays a limited role in metabolic inflammation. 

Lownik JC, Farrar JS, Pearce JV, Celi FS, Martin RK.

Adipocyte. 2020 Dec;9(1):509-522.

Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition. 

Kakiyama G, Marques D, Martin RK, Takei H, Rodriguez-Agudo D, LaSalle SA, Hashiguchi T, Liu X, Green RM, Erickson SK, Gil G, Fuchs M, Suzuki M, Murai T, Nittono H, Hylemon PB, Zhou H, Pandak WM.

J Lipid Res. 2020 Oct 2;.

Immunization against Anaplasma phagocytophilum Adhesin Binding Domains Confers Protection against Infection in the Mouse Model. 

Naimi WA, Gumpf JJ, Green RS, Izac JR, Zellner MP, Conrad DH, Marconi RT, Martin RK, Carlyon JA.

Infect Immun. 2020 Sep 18;88(10).

Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells. 

Paez PA, Kolawole M, Taruselli MT, Ajith S, Dailey JM, Kee SA, Haque TT, Barnstein BO, McLeod JJA, Caslin HL, Kiwanuka KN, Fukuoka Y, Le QT, Schwartz LB, Straus DB, Gewirtz DA, Martin RK, Ryan JJ.

J Pharmacol Exp Ther. 2020 Jul;374(1):104-112.

The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer. 

Luker AJ, Graham LJ, Smith TM Jr, Camarena C, Zellner MP, Gilmer JS, Damle SR, Conrad DH, Bear HD, Martin RK.

BMC Immunol. 2020 Feb 27;21(1):8. 

B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138. 

Lownik JC, Wimberly JL, Takahashi-Ruiz L, Martin RK.

Biochem Biophys Res Commun. 2020 Feb 5;522(2):442-447. 

Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection. 

Green RS, Naimi WA, Oliver LD Jr, O’Bier N, Cho J, Conrad DH, Martin RK, Marconi RT, Carlyon JA.

mBio. 2020 Jan 28;11(1).

The Il9 CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production. 

Abdul Qayum A, Koh B, Martin RK, Kenworthy BT, Kharwadkar R, Fu Y, Wu W, Conrad DH, Kaplan MH.

J Immunol. 2019 Sep 1;203(5):1111-1121. 

A Disintegrin and Metalloproteinase 17 is required for ILC2 responses to IL-33.

Lownik JC, Conrad DH, Martin RK.

Biochem Biophys Res Commun. 2019 May 14;512(4):723-728.

Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens.

Cockburn CL, Green RS, Damle SR, Martin RK, Ghahrai NN, Colonne PM, Fullerton MS, Conrad DH, Chalfant CE, Voth DE, Rucks EA, Gilk SD, Carlyon JA.

Life Sci Alliance. 2019 Mar 22;2(2). pii: e201800292.

B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis.

Lownik JC, Wimberly JL, Conrad DH, Martin RK.

J Immunol. 2019 Feb 1;202(3):664-674.

The Obligate Intracellular Bacterium Orientia tsutsugamushi Targets NLRC5 To Modulate the Major Histocompatibility Complex Class I Pathway.

Rodino KG, Adcox HE, Martin RK, Patel V, Conrad DH, Carlyon JA.

Infect Immun. 2019 Feb 21;87(3). pii: e00876-18.

B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade.

Martin RK, Damle SR, Valentine YA, Zellner MP, James BN, Lownik JC, Luker AJ, Davis EH, DeMeules MM, Khandjian LM, Finkelman FD, Urban JF Jr, Conrad DH.

Cell Rep. 2018 Feb 13;22(7):1824-1834.

ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.

Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK, El Shikh MEM, Conrad DH.

J Immunol. 2017 Oct 1;199(7):2305-2315.

ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production.

Damle SR, Martin RK, Cockburn CL, Lownik JC, Carlyon JA, Smith AD, Conrad DH.

Allergy. 2018 Jan;73(1):125-136.

Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis.

Damle SR, Martin RK, Cross JV, Conrad DH.

Mucosal Immunol. 2017 Jan;10(1):205-214.

Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.

Cooley LF, Martin RK, Zellner HB, Irani AM, Uram-Tuculescu C, El Shikh ME, Conrad DH.

PLoS One. 2015 May 1;10(5):e0124331.

Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses.

Morales JK, Saleem SJ, Martin RK, Saunders BL, Barnstein BO, Faber TW, Pullen NA, Kolawole EM, Brooks KB, Norton SK, Sturgill J, Graham L, Bear HD, Urban JF Jr, Lantz CS, Conrad DH, Ryan JJ.

J Leukoc Biol. 2014 Apr;95(4):643-50.

Antigen transfer from exosomes to dendritic cells as an explanation for the immune enhancement seen by IgE immune complexes.

Martin RK, Brooks KB, Henningsson F, Heyman B, Conrad DH.

PLoS One. 2014 Oct 20;9(10):e110609.

Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells.

Martin RK, Saleem SJ, Folgosa L, Zellner HB, Damle SR, Nguyen GK, Ryan JJ, Bear HD, Irani AM, Conrad DH.

J Leukoc Biol. 2014 Jul;96(1):151-9.

Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity.

Saleem SJ, Martin RK, Morales JK, Sturgill JL, Gibb DR, Graham L, Bear HD, Manjili MH, Ryan JJ, Conrad DH.

J Immunol. 2012 Jul 15;189(2):511-5.

A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture.

Chaimowitz NS, Martin RK, Cichy J, Gibb DR, Patil P, Kang DJ, Farnsworth J, Butcher EC, McCright B, Conrad DH.

J Immunol. 2011 Nov 15;187(10):5114-22.

Book Chapters

A Disintegrin and Metalloproteinase (ADAM) 10 and 17 in Th2 Mediated Responses

Folgosa-Cooley L, Martin RK, Conrad DH

DOI: 10.5772/59396