Publications | The Rebecca Martin Laboratory

Research Articles

D-2-hydroxyglutarate suppresses allergic sensitization in a murine model of experimental asthma

Tharakan A, Kumar A, Allegood J, Cowart LA, Conrad DH, Martin RK

Allergy. 2023 DOI: 10.1111/all.15809.

Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by releasing ACE2 from the epithelial surface.

Kummarapurugu AB, Hawkridge A, Ma J, Osei S, Martin RK, Voynow J.

Journal of Biological Chemistry. 2023 DOI: 10.1016/j.jbc.2023.104820.

Reduction of Neutrophil Extracellular Traps Accelerates Inflammatory Resolution and Increases Appositional Bone on Titanium Implants.

Morandini L, Avery D, Angeles B, Winston P, Martin RK, Donahue HJ, Olivares-
Navarrete R.

Acta Biomaterialia. 2023 DOI: 10.1016/j.actbio.2023.05.016

Immune Cell Response to Orthopedic and Craniofacial Biomaterials Depends on Biomaterial Composition.

Avery D, Morandini L, Celt N, Bergey L, Simmons J, Martin RK, Donahue HJ, Olivares-Navarrete R.

Acta Biomaterialia. 2023 DOI: 10.1016/j.actbio.2023.03.007

Neutrophilia in Severe Asthma is reduced in Ormdl3 Overexpressing Mice.

James BN, Weigel C, Green CD, Brown RDR, Palladino END, Tharakan A, Milstein S,
Proia RL, Martin RK, Spiegel S

FASEB Journal. 2023 DOI: 10.1096/fj.202201821R

Coffee modulates insulin-HNF-4α-Cyp7b1 pathway and reduces oxysterol driven liver toxicity in a NAFLD mouse model.

Kakiyama G, Minowa K, Rodriguez-Agudo D, Martin RK, Takei H, Mitamura K, Ikegawa
S, Mitsuyoshi S, Nittono H, Fuchs M, Heuman D, Zhou H, Pandak W.

American Journal of Physiology. 2022 DOI: 10.1152/ajpgi.00179.2022

Melanoma differentiation associated gene-9/syndecan binding protein (MDA-
9/SDCBP) promotes hepatocellular carcinoma (HCC).

Manna D, Reghupaty S, Camarena C, Mendoza R, Subler M, Koblinski J, Martin RK,
Dozmorov M, Mukhopadhyay N, Liu J, Qu X, Das S, Lai Z, Windle J, Fisher P, Sarkar
D.

Hepatology. 2022 DOI: 10.1002/hep.32797

Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis

Biswas DD, Martin RK, Brown LN, Mockenhaupt K, Gupta AS, Surace MJ, Tharakan A, Yester JW, Bhardwaj R, Conrad DH, Kordula T

J Neuroinflammation. 2022 DOI: 10.1186/s12974-022-02527-6.

Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin

Rajesh Y, Reghupaty SC, Mendoza RG, Manna D, Banerjee I, Subler MA, Weldon K, Lai Z, Giashuddin S, Fisher PB, Sanyal AJ, Martin RK, Dozmorov MG, Windle JJ, Sarkar D.

Hepatol Commun. 2022. DOI: 10.1002/hep4.1834

Fast SARS-CoV-2 Variant Detection Using Snapback Primer High-Resolution Melting

Lownik JC, Farrar JS, Way GW, McKay A, Roychoudhury P, Greninger AL, Martin RK

Diagnostics. 2021. DOI: 10.3390/diagnostics11101788

Extraction-Free Rapid Cycle Quantitative RT-PCR and Extreme RT-PCR for SARS-CoV-2 Virus Detection

Lownik JC, Way GW, Farrar JS, Martin RK

J Mol Diagnostics. 2021 DOI: 10.1016/j.jmoldx.2021.08.004

Identification of the transgene insertion site for an adipocyte-specific adiponectin-cre model and characterization of the functional consequences

Farrar JS, Lownik JC, Way GW, Rodriguez MC, Celi FS, Martin RK.

Adipocyte. 2021 DOI: 10.1080/21623945.2021.1880083

Stat5B is required for IgE-Mediated mast cell function in vitro and in vivo.

Kiwanuka KN, Montunrayo Kolawole E, McLeod JJA, Baker B, Paez PA, Zellner MP, Haque TT, Paranjape A, Jackson K, Kee SA, Dailey J, Martin RK, Ryan JJ.

Cellular Immunol. 2021 DOI: 10.1016/j.cellimm.2021.104344

Ceremide in apoptosis and oxidative stress in allergic inflammation and asthma

James BN, Oyeniran C, Sturgill JL, Newton J, Martin RK, Bieberich E, Weigel C, Maczis M, Palladino END, Lownik JC, Trudeau BA, Cook-Mills JM, Wenzel S, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2020 DOI: 10.1016/j.jaci.2020.10.024

Adipocyte ADAM17 plays a limited role in me tabolic inflammation.

Lownik JC, Farrar JS, Pearce JV, Celi FS, Martin RK.

Adipocyte. 2020 Dec;9(1):509-522.

Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition.

Kakiyama G, Marques D, Martin RK, Takei H, Rodriguez-Agudo D, LaSalle SA, Hashiguchi T, Liu X, Green RM, Erickson SK, Gil G, Fuchs M, Suzuki M, Murai T, Nittono H, Hylemon PB, Zhou H, Pandak WM.

J Lipid Res. 2020 Oct 2;.

I mmunization against Anaplasma phagocytophilum Adhesin Binding Domains Confers Protection against Infection in the Mouse Model.

Naimi WA, Gumpf JJ, Green RS, Izac JR, Zellner MP, Conrad DH, Marconi RT, Martin RK, Carlyon JA.

Infect Immun. 2020 Sep 18;88(10).

Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells.

Paez PA, Kolawole M, Taruselli MT, Ajith S, Dailey JM, Kee SA, Haque TT, Barnstein BO, McLeod JJA, Caslin HL, Kiwanuka KN, Fukuoka Y, Le QT, Schwartz LB, Straus DB, Gewirtz DA, Martin RK, Ryan JJ.

J Pharmacol Exp Ther. 2020 Jul;374(1):104-112.

The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.

Luker AJ, Graham LJ, Smith TM Jr, Camarena C, Zellner MP, Gilmer JS, Damle SR, Conrad DH, Bear HD, Martin RK.

BMC Immunol. 2020 Feb 27;21(1):8.

B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138.

Lownik JC, Wimberly JL, Takahashi-Ruiz L, Martin RK.

Biochem Biophys Res Commun. 2020 Feb 5;522(2):442-447.

Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection.

Green RS, Naimi WA, Oliver LD Jr, O’Bier N, Cho J, Conrad DH, Martin RK, Marconi RT, Carlyon JA.

mBio. 2020 Jan 28;11(1).

The Il9 CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production.

Abdul Qayum A, Koh B, Martin RK, Kenworthy BT, Kharwadkar R, Fu Y, Wu W, Conrad DH, Kaplan MH.

J Immunol. 2019 Sep 1;203(5):1111-1121.

A Disintegrin and Metalloproteinase 17 is required for ILC2 responses to IL-33.

Lownik JC, Conrad DH, Martin RK.

Biochem Biophys Res Commun. 2019 May 14;512(4):723-728.

Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens.

Cockburn CL, Green RS, Damle SR, Martin RK, Ghahrai NN, Colonne PM, Fullerton MS, Conrad DH, Chalfant CE, Voth DE, Rucks EA, Gilk SD, Carlyon JA.

Life Sci Alliance. 2019 Mar 22;2(2). pii: e201800292.

B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis.

Lownik JC, Wimberly JL, Conrad DH, Martin RK.

J Immunol. 2019 Feb 1;202(3):664-674.

The Obligate Intracellular Bacterium Orientia tsutsugamushi Targets NLRC5 To Modulate the Major Histocompatibility Complex Class I Pathway.

Rodino KG, Adcox HE, Martin RK, Patel V, Conrad DH, Carlyon JA.

Infect Immun. 2019 Feb 21;87(3). pii: e00876-18.

B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade.

Martin RK, Damle SR, Valentine YA, Zellner MP, James BN, Lownik JC, Luker AJ, Davis EH, DeMeules MM, Khandjian LM, Finkelman FD, Urban JF Jr, Conrad DH.

Cell Rep. 2018 Feb 13;22(7):1824-1834.

ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.

Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK, El Shikh MEM, Conrad DH.

J Immunol. 2017 Oct 1;199(7):2305-2315.

ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production.

Damle SR, Martin RK, Cockburn CL, Lownik JC, Carlyon JA, Smith AD, Conrad DH.

Allergy. 2018 Jan;73(1):125-136.

Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis.

Damle SR, Martin RK, Cross JV, Conrad DH.

Mucosal Immunol. 2017 Jan;10(1):205-214.

Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.

Cooley LF, Martin RK, Zellner HB, Irani AM, Uram-Tuculescu C, El Shikh ME, Conrad DH.

PLoS One. 2015 May 1;10(5):e0124331.

Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses.

Morales JK, Saleem SJ, Martin RK, Saunders BL, Barnstein BO, Faber TW, Pullen NA, Kolawole EM, Brooks KB, Norton SK, Sturgill J, Graham L, Bear HD, Urban JF Jr, Lantz CS, Conrad DH, Ryan JJ.

J Leukoc Biol. 2014 Apr;95(4):643-50.